Wellbutrin insomnia harvard8/7/2023 Not suitable for the treatment of panic disorder and concomitant phobic disorder but may improve symptoms of panic in those with depression.This risk is increased with higher dosages of bupropion, in those with head injuries or taking other medications which also lower the seizure threshold. The risk is greatest for children and young adults under the age of 24. As with other antidepressants, bupropion may increase the risk of suicidal thoughts or behavior.Not approved for use in children under the age of 18 years.May not be suitable for some people including those with seizure disorders eating disorders undergoing alcohol, anticonvulsant, barbiturate, or benzodiazepine withdrawal at risk of glaucoma already taking bupropion for another indication (such as smoking cessation) pregnant or breastfeeding or a history of allergy to bupropion or monoamine oxidase inhibitor use within the past two weeks.Extended-release tablets should be administered twice daily (but may be administered once daily on initiation).Dosages of 300mg or more should be split into divided doses that do not exceed 150mg each. Avoid bedtime administration of the evening dose to reduce the incidence of insomnia. Preferably at least 6 hours should separate doses (eg, in the morning, midday, and in the evening). Conventional tablets may need to be taken up to three times daily.Active metabolites may accumulate and increase the risk of seizures. The dosage of bupropion requires adjusting in kidney and liver disease.Blood pressure should be taken on treatment initiation and monitored periodically. More likely than other antidepressants to cause weight loss however, may also cause weight gain in some people.Most cases resolved on discontinuation of bupropion however, a few persisted. People should be monitored for the appearance of neuropsychiatric symptoms. Symptoms have occurred in people with and without pre-existing psychiatric disease. Severe neuropsychiatric symptoms, including agitation, anxiety, delusions, hallucinations, panic disorder, paranoia, and psychosis have been reported with bupropion use and it carries a black box warning for these effects.May also cause abdominal pain, abnormal dreams, flushing, muscle and joint pain, migraine, rash, or itchy skin. Insomnia, headache, dizziness, dry mouth, sore throat, nausea, and constipation are the more commonly reported side effects.If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Generic bupropion is available and bupropion is also marketed under the brand name Aplenzin (for depression) and Zyban (for smoking cessation).May be used off-label (not an FDA-approved use but considered by some expert organizations as an option if standard treatments are not effective or tolerated) for attention deficit hyperactivity disorder (ADHD).Zyban may also be combined with a Nicotine Transdermal System (nicotine patches), although blood pressure should be monitored. Research has shown that treatment with Zyban is significantly more effective at helping people to quit smoking than no treatment. Bupropion (Zyban brand, generic bupropion) may be used to relieve cravings associated with nicotine withdrawal during smoking cessation.May be considered second-line for the treatment of bipolar depression when first-line agents are not effective or tolerated.
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